Abstract
Glioblastoma is one of the most aggressive human cancers. Despite current advances in multimodality therapies, such as surgery, radiotherapy and chemotherapy, the outcome for patients with this neoplasia remains fatal. Thus, novel effective treatment regimens are urgently needed.Tetra-O-methyl nordihydroguaiaretic acid (M4N), a global transcription inhibitor of Sp1-regulated genes, has sh…