CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Farmácia Bioquímica from Universidade de São Paulo (2006) and doctorate at Physiology from Universidade de São Paulo (2012). Has experience in Physiology, focusing on General Physiology, acting on the following subjects: nitric oxide, biotelemetry, body temperature and v1-receptor antagonist. (Source: Lattes Curriculum)
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Sepsis and multiple organ dysfunction consist of a public health issue, with high costs on the health systems, and currently comprise the main cause of mortality in intensive care units. The intestine is a severely affected organ in sepsis, whose dysfunction includes dysmotility, decreased absorptive capacity and loss of the mucosal barrier. The structural damages on the junctional comple…
Changes in functioning of the gastrointestinal tract (nausea, vomiting, diarrhea and abdominal discomfort) have been described in pandemics by coronavirus in 2003 and 2019. Accordingly, experimental data in rodents confirm that respiratory viral infections promote disorders of the intestinal functions including increased motility, loss/malabsorption of fluids, inflammation of the intestin…
The intestinal mucosa plays a critical role in the organism, acting as a barrier for separation between the lamina propria and the external environment existing in the intestinal lumen. The systemic inflammation is a primary injury to this epithelium, promoting change in intestinal permeability and bacterial translocation. The proinflammatory mediators synthesized during endotoxemia, such…
The intense activation of the systemic inflammatory response induced by sepsis has been associated with the generation of free radicals by multiple cell types. It is evident that several deleterious effects attributed to nitric oxide (NO) in sepsis are, in fact, indirectly mediated by peroxynitrite (ONOO). Peroxynitrite has been recognized as responsible for some sepsis associated complic…
Sepsis is a multifactorial syndrome caused by an unbalanced host response to infection. The intestinal epithelial barrier allows selective permeation of molecules and ions and prevents the passage of microorganisms from the lumen into the blood and lymph stream. However, the inflammatory response can induce increased intestinal permeability, which leads to potential systemic dissemination…
Sepsis is characterized by organ dysfunction as a consequence of exacerbated inflammatory response against infection. In its acute phase, it is not only associated with a high concentration of pro-inflammatory cytokines, but also with feedback and perpetuation of the response due to tissue damage caused by this process. Among the infected organs is the intestine, which, due to the extensi…
| 3 / 3 | Completed research grants |
| 5 / 3 | Completed scholarships in Brazil |
| 8 / 6 | All research grants and scholarships |
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