Abstract
Bites by Loxosceles spiders can produce severe clinical symptoms, including dermonecrosis, thrombosis and haemolysis. Renal failure is one of the major causes of death after Loxosceles envenomation, and recently we have started to investigate the mechanism of renal dysfunction induced by Loxosceles venom. The sphingomyelinase D (SMase D) is the main factor in Loxosceles spider venom respo…