Abstract
Dyskeratosis Congenita (DC) is a rare inherited syndrome characterized by mucocutaneous manifestations, bone marrow (BM) failure and increased susceptibility to cancer. X-linked DC (DC-X) is the most severe form of the syndrome and is caused by mutations in the DKC1 gene that encodes dyskerin, a putative pseudouridine synthase which mediate the posttranscriptional modification of ribosoma…