Abstract
Alzheimer's disease (AD) is characterized by a progressive cognitive decline associated with accumulation of ²-amyloid peptide (neuritic plaques), hyperphosphorylated tau protein (neurofibrillary tangles), synaptic degeneration and neuronal death in the hippocampus and other cortical regions. Studies have found that AD has a hypometabolism and a compromised mitochondrial bioenergetics, as…