CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Medicina from Faculdade de Ciências Médicas da Santa Casa de São Paulo (1980) and ph.d. at Hematologia from Faculdade de Medicina da Universidade de São Paulo (1997). Has experience in Medicine, focusing on Clinical Medicine, acting on the following subjects: lmc, ck-19, biologia molecular, bcr-abl and thrombophilia. (Source: Lattes Curriculum)
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Chronic myeloid leukemia (CML) was the first neoplasm in humans associated with a chromosome rearrangement. It is characterized by the presence of the Philadelphia (Ph)chromosome, resulting from the fusion of part of the proto-oncogene ABL1, on chromosome 9 with the BCR gene, on chromosome 22, generating the BCR-ABL fusion gene. The gene product is a chimeric protein with high tyrosine ki…
Several studies have suggested that treatments with decreasing imatinib mesylate's dosing, starting in 800 mg / day to 400 mg / day present better response to treatment of chronic phase CML. These results have been obtained by monitoring blood levels of imatinib and comparison to response indicators to imatinib or other TKI, as Hematologic Response (HR) Cytogenetic Response (CR) and Molec…
| 5 / 2 | Completed research grants |
| 2 / 1 | Completed scholarships in Brazil |
| 7 / 3 | All research grants and scholarships |
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