CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Ciências Biológicas Modalidade Médica from Centro Universitário Barão de Mauá (1999), master's at Applied Imunology from Universidade de São Paulo (2005) and doctorate at Imunologia Basica e Aplicada from Faculdade de Medicina de Ribeirão Preto-Universidade de São Paulo (2009). Has experience in Immunology, focusing on Immunology, acting on the following subjects: leishmania braziliensis, anti-inflammatory mediators, inflammation, sand fly and antigen presentation. (Source: Lattes Curriculum)
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This proposal is a continuation of a research line that we have developed. Recently, we had made progress understanding the role of innate immunity receptors, such TLRs, modulating the immune response during experimental VL. While the signaling pathways mediated by TLR2 and TLR9 appear to promote the development of an effector immune response, which controls parasite replication, the path…
Visceral Leishmaniasis (VL) is a serious problem of public health, causing high morbidity and mortality in several countries, including Brazil. Among those infected, 85% remain asymptomatic, while the remaining 15% present clinical manifestations, ranging from oligosymptomatic forms (mild) to more severe symptomatic forms that may evolve to death. In the absence of efficient and effective…
The complexity of the immune response against Leishmania infantum, protozoa parasites causative of visceral leishmaniasis (VL) in Brazil, is represented by the high diversity of factors involved in the parasite-host relationship, focusing on the immune response. The cellular immune response is involved in the clinical outcome, in which the resistance profile is associated to the Th1-lymph…
The regulation of intensity and magnitude of immune responses in infectious process need to be precisely orchestrated in order to promote the control of the pathogens and prevent the development of immunopathology. The visceral leishmaniases (VL) is a chronic disease and potentially fatal, if not properly treated. Patient with severe VL present a clinical condition called "cytokine storm"…
IL-1 affects many cells and organs and is an important immunity mediator. According to our results (FAPESP process Number 2017/04347-6), during the chronic phase of visceral leishmaniasis (VL), IL-1alpha is induced in the gut and promotes intestinal mucosal integrity through the induction of tight junctions to avoid microbiota translocation. Consequently, it prevented an exacerbated Th1 r…
Neutrophils are generally the first phagocytes to migrate during infection caused by Leishmania protozoa parasites to the infectious focus. Its protective effect is directly associated with its ability to phagocyte, activate and eliminate the parasites. After ingestion, the pathogen particles are eliminated through oxidative and non-oxidative mechanisms. The oxidative mechanisms involve t…
| 2 / 2 | Completed research grants |
| 3 / 2 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 7 / 6 | All research grants and scholarships |
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