Abstract
The transcriptional modulation of pain-related genes in co-cultures of 3D neural spheroids (neurons, glial cells and Schwan cells) and 3D mimic of cartilage microenvironment (cultured with chondrocytes, synovicytes and macrophages) will be studied by RT_PCR arrays. The double 3D co-culture model allows for the in vitro modelling of the complex environment of joints and the peripheral noci…