Fernando Silva Carneiro

• Abstract

  Obese men are at high risk for the development of erectile dysfunction (ED). The prevalence of obesity in men reporting ED symptoms may be as high as 79%. Abdominal adiposity, determined by waist circumference, is implicated as a risk factor for ED. In addition, the severity of ED correlates positively with increased abdominal adiposity. A common mechanism between obesity and ED is endoth…

  Erectile dysfunction induced by high fat diet: the role of TNF-alpha, AP.R

• Abstract

  Endothelin-1 (ET-1) is a potent vasoconstrictor peptide secreted by vascular endothelial cells. After its initial discovery, it has become more evident that ET-1 is involved in several pathophysiological processes other than just controlling vascular tone, such as remodelling, fibrosis, apoptosis, hypertrophy and inflammation. Therefore, ET-1 system imbalances has been associated to diffe…

  NLRP3 contribution to the pro-inflammatory effect of ET-1 in corpora cavernosa smooth muscle cells: relevance in erectile function., AP.R

• Abstract

  Androgen deficiency is strongly associated with erectile dysfunction (ED). Inadequate penile arterial blood flow is one of the major causes of ED. The blood flow to the corpus cavernosum is mainly derived from the internal pudendal arteries (IPAs); however, no study has evaluated the effects of androgen deprivation on IPAs function. We hypothesized that castration impairs IPAs reactivity …

  Functional and structural changes in internal pudendal arteries underlie erectile dysfunction induced by androgen deprivation, PUB.ART

(Only some records are available in English at this moment)

• Abstract

  Erectile dysfunction (ED) is defined as the inability to achieve or maintain an erection of the penis for satisfactory sexual intercourse. ED is often associated with risk factors for developing cardiovascular diseases such as hypertension and / or metabolic diseases such as diabetes and dyslipidemia. Hypertension has become a growing public health problem, it is an important risk factor…

  The NLRP3 role in erectile dysfunction in hypertensive model DOCA / salt and its possible activation by ET-1, BP.DR
• Mechanisms of erectile dysfunction on heart failure, BP.JP

• Abstract

  Erectile dysfunction (ED) is often associated with risk factors for the development of cardiovascular diseases such as arterial hypertension. Arterial hypertension is a public health problem because it is an important risk factor for the development of other cardiovascular, cerebrovascular and renal diseases. In addition, ED occurs twice as frequent as in patients with arterial hypertensi…

  The Role Of Calcium-Activated Potassium Channels 2.3 (KCa 2.3) In The Inhibition Of Endothelin-1 (ET-1)-Induced NLRP3 Activation And Impairment Of The Erectile Function In DOCA/Salt Model Of Arterial Hypertension, BE.EP.DR