CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Odontologia from Universidade de Mogi das Cruzes (2001), master's at Biochemistry from Universidade Federal de São Paulo (2003) and ph.d. at Biochemistry from Universidade Federal de São Paulo (2006). Has experience in Odontology, focusing on Odontology, acting on the following subjects: catepsina b, cathepsin b, cathepsina b, câncer and cathepsin x. (Source: Lattes Curriculum)
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The extracellular matrix (ECM) is constantly remodeling in response to various extracellular and intracellular stimuli, and the way in which these signals are transmitted, captured and interpreted by cells, determines and differentiates the fate of normal or pathological remodeling. Response to stimuli is a hallmark of the definition of life. Communication between cells is essential and i…
Worldwide, dental caries is the most common chronic disease, with a significant impact on public health expenditures and the quality of life of individuals. Epidemiological data indicate the situation is critical in several countries, affecting 60-90% of school-age children. Despite the advances that have occurred in recent years regarding materials and techniques used for oral hygiene, d…
The many mechanisms whereby proteolytic enzymes can regulate cell functions have been only elucidated in the late 60's, when the generation or degradation of active polypeptides, was established. Since that time, proteinases have taken on a new life as hormone-like signal messengers. The search for a receptor that can be activated through the hydrolysis of its extracellular portion and su…
The PAR family of receptors plays a vital role in many processes like hemostasis, inflammation, embryonic development, and the pathogenesis of some types of cancer. Different genes code all four members of this receptor family, and their expressions vary based on the species and cell type being studied. The activation of PARs occurs due to the proteolytic cleavage of a specific peptide se…
This project aims to: 1) evaluate and characterize and cellular interactions with pAsp e/ou pGlu 2) bioprint a mineralizable 3D dentin matrix (scaffold) and 3) evaluate the mechanisms by which pAsp and/or pGlu can modulate the dentin neoformation process. Therefore, this project was divided in phases. Phase I: evaluation and characterization of cellular interactions with the pAsp and/or p…
The heyday of regenerative medicine has a title that is well known, stem cells. In dental medicine, several studies converge to the development of mechanisms that use stem cells for and replacement of buccal tissues, since dental and periodontal tissue loss are common abnormalities that irreversibly threaten the general health of the patient. However, so far, the protocols for rehabilitat…
| 2 / 2 | Ongoing grants |
| 2 / 1 | Completed research grants |
| 4 / 3 | Completed scholarships in Brazil |
| 8 / 6 | All research grants and scholarships |
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