Abstract
Anaplasma marginale is an obligate gram-negative alpha-proteobacterium that causes bovine anaplasmosis, a very important rickettsiosis in Brazil. In the host, it infects bovine erythrocytes and on its biological vector, the tick, the bacteria infects intestinal endothelium and salivary glands. Treatment for the clinical disease has long been the use of antibiotics such as oxytetracycline,…