Abstract
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the clinical tetrad tremor, rigidity, akinesia (or bradykinesia) and postural instability. The tremor typically starts asymmetrically and is present at rest, usually involving hands, legs, jaw, lips, but sparing the head. Pathologically, PD is classified as a synucleinopathy associated predominantly with the loss of…