Abstract
AIRE is a nuclear transcription factor that participates in the negative selection of lymphocytes in the thymus. Patients deficient in this protein develop a rare syndrome known as Autoimmune polyendocrinopathy-Associated Candidiasis and Ectodermal Dystrophy (APECED). This syndrome is a primary immunodeficiency characterized by the presence of various autoantibodies, hypoparathyroidism, A…