Abstract
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. Characteristically occurs depletion of the amount of motor neurons and inflammation in the central nervous system. ALS is a multifactorial disease and most cases are sporadic. Familial ALS comprises 5 to 10% of cases. Among the genes identified for this disease is the SOD1 gene that encodes an important antioxidant …