Afonso Caricati Neto

CV Lattes Google Scholar Citations

Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal)
Birthplace: Brazil

graduate at Ciências Biológicas from Universidade Estadual Paulista Júlio de Mesquita Filho (1983), graduate at Ciencias Biologicas - Bacharelado from Universidade Estadual Paulista - Júlio de Mesquita Filho (1984), master's at Pharmacology from Universidade Federal de São Paulo (1989) and ph.d. at Pharmacology from Universidade Federal de São Paulo (1996). Has experience in Pharmacology, focusing on Pharmacology Molecular Biochemistry, acting on the following subjects: neurotransmissão, mecanismo de ação de drogas, musculo liso, homeostase celular do cálcio and ischemia-reperfusion lesions. (Source: Lattes Curriculum)

News published in Agência FAPESP Newsletter about the researcher

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Research grants

Completed (most recent)

Abstract
Abstract - Characterized by severe motor dysfunctions resulting from the degeneration and death of dopaminergic (DA) neurons mainly from the substantia nigra (SN), Parkinson's disease (PD) is the second most common neurodegenerative disorder in developed countries. There is no cure or proven strategy for slowing the progression of this disease. Although the pathophysiological mechanisms o…
New therapeutic approach of the Parkinson´s disease: Neuroprotection stimulated by pharmacological modulation of the intracellular signaling by Ca2+/cAMP/NO, AP.R

Scholarships in Brazil

Completed (most recent)

Abstract
A recent study from our lab unraveled the mechanisms involved in the cellular process called the "calcium paradox." The study demonstrated that reducing Ca2+ influx through L-type voltage-dependent Ca2+ channel blockers, such as verapamil, combined with drugs that increase cytosolic cAMP concentration, such as rolipram, promoted potentiation of the contractile activity of smooth muscle, r…
Implications of the interaction between signaling pathways mediated by Ca2+ and cAMP in the regulation of sympathetic activity: advances for antihypertensive drug therapy, BP.IC
Abstract
Study of our laboratory recently published in the british journal specialized in the studyof the role of Ca2+ in cell function Cell Calcium ( vol. 54 , 2013 ) unraveled themechanisms involved in the cellular process called "calcium paradox ." Elected as oneof the most accessed papers in all existence in this journal(http://top25.sciencedirect.com/subject/biochemistry-genetics-and-molecula…
Role of the "calcium paradox" in sympathetic function in hypertensive animals and their possible implications for antihypertensive pharmacologic strategies, BP.PD

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2 / 1	Completed research grants
2 / 2	Completed scholarships in Brazil
4 / 3	All research grants and scholarships

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Most frequent collaborators in research granted by FAPESP

Keywords used by the researcher

Biological Sciences Pharmacology

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Abstract

Abstract

Abstract