Abstract
Marfan syndrome (MFS) is an autosomal dominant disease of the connective tissue which affects about 1 in 5,000 individuals, and is caused by mutations in FBN1 gene, which encodes the extracellular matrix protein fibrillin-1. The main clinical manifestations include aneurysms and aortic rupture, excessive growth of bones, scoliosis and chest deformities, lens dislocation and myopia. Despit…