CV Lattes
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Universidade de São Paulo (USP). Escola de Artes, Ciências e Humanidades (EACH) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduated in Chemistry (1995) obtained his Ph.D. degree in Biochemistry (2001) both at University of São Paulo . He extended his career in two postdoctoral trainings, the first one at University of Texas Southwestern Medical Center at Dallas (2005), and the second one at São Carlos Physics Instuitute (IFSC-USP, 2006). Currently, he is a principal investigator at University of São Paulo, and develops research focused in genetics, biochemistry and molecular biology of the yeast Saccharomyces cerevisiae, oriented to the understading of the retrograde signaling, the pathway of communication between mitochondria and nucleus, and the molecular mechanisms of aging. (Source: Lattes Curriculum)
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Mucopolysaccharidoses comprise a subclass of lysosomal diseases caused by a deficiency in the enzymes that catabolize glycosaminoglycans; charged carbohydrates that accumulate in the lysosomes and cause pathologic bone, cardiopulmonary, auditive, and neurocognitive phenotypes. Sanfilippo syndrome is the mucopolysaccharidosis (MPS) whose treatment is more difficult, and this MPS involves s…
Apoptosis is a highly organized active process of cell death that participates in organogenesis and tissue remodeling during embryonic development. In the immune system, apoptosis is involved in the negative selection of lymphoid lineage cells; it eliminates neoplastic cells and those infected by virus, after the action of cytotoxic T lymphocytes and natural killer cells. Alterations in t…
The aging population is constantly growing, and accompanies a higher incidence of chronic and neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington. These diseases are caused by the accumulation of unfolded proteins, and studies have indicated that the components of the ubiquitin-proteasome system are a potential therapeutic target for diseases related to the senile p…
Cells of the baker´s yeast Saccharomyces cerevisiae can adapt their metabolism in response to the physiological state of their mitochondria by activating the nuclear transcription, an interorganelle communication known as retrograde signaling. This signaling is controlled by the transcription factor complex Rtg1p-Rtg3p. When mitochondrial activity is high the complex is sequestered in the…
Oleaginous yeasts are microorganisms capable of producing and storing more than 20% of their biomass in the form of lipids. Yarrowia lipolytica, an oleaginous yeast, stands out for its ability to store more than 40% lipids in its dry biomass in the form of lipid particles (LDs) and convert various carbon sources into triacylglycerols (TAGs) and sterol esters (SEs) during the stationary ph…
Oleaginous yeasts are microorganisms capable of producing and storing more than 20% of their biomass in the form of lipids. Yarrowia lipolytica, an oleaginous yeast, stands out for its ability to store more than 40% lipids in its dry biomass in the form of lipid particles (LDs) and convert various carbon sources into triacylglycerols (TAGs) and sterol esters (SEs) during the stationary ph…
Apoptosis is a highly organized active cell death process that aids organogenesis and tissue remodeling during embryonic development. In the immune system, apoptosis participates in the negative selection of cells of the lymphoid lineage, and eliminates neoplastic and virus-infected cells, after the action of cytotoxic T lymphocytes and natural killer cells. Changes in apoptosis inducing …
| 1 / 1 | Ongoing grants |
| 3 / 3 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 1 / 1 | Completed scholarships in Brazil |
| 7 / 7 | All research grants and scholarships |
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