Abstract
Purinergic receptors activation (P2R) by adenosine 5'-triphosphate (ATP) in the central nervous system (CNS) appears to be involved in anxiety responses. Studies indicate that activation of P2R modulates the synthesis of nitric oxide (NO) via activation of the neuronal isoform of NO synthase (nNOS). There is evidence that administration of nNOS inhibitor decreases the expression and facil…