Abstract
Acute promyelocytic leukemia (APL) is characterized by the infiltration of bone marrow and peripheral blood by leukemic cells presenting a block of differentiation at the stage of promyelocytes. The majority of APL cases (98%) is associated with the t(15;17)(q22;q21) which causes the fusion of two genes: Retinoic Receptor ± (RAR±) and Promyelocytic Leukemia (PML), on chromosomes 17 and 15…