Abstract
The mitochondrial NAD(P)+ transhydrogenase (NNT) is a transmembrane protein that catalyzes the transfer of hydride between NAD(H) and NADP(H) coupled with proton transport between the intermembrane space and the mitochondrial matrix. This process can occur in both directions and generate either NADPH or NADH (i.e., forward and reverse reactions). Although both reactions are physiologicall…