Abstract
Sickle cell anemia (SCA) occurs due to molecular alterations in the beta globin gene. The key event in the pathogenesis of sickle cell anemia is deoxy-HbS polymerization. Deoxy-HbS polymerization depends on some factors such as: oxygen concentration, pH, concentration of HbS, temperature, pressure, ionic strength and the presence of normal hemoglobin. The consequences of polymerization ar…