Abstract
Regulation of Ca2+ homeostasis in trypanosomes differs significantly from that in mammalian cells. Trypanosomes possess an abundant acidic calcium store, the acidocalcisome, which is also rich in polyphosphate. Recent results from our group have indicated that acidocalcisomes possess an inositol 1,4,5-trisphosphate receptor (IP3R). These channels are usually located in the endoplasmic ret…