Maria de Fátima Magalhães Lazari

• Abstract

  An especially important time of the physiology of Sertoli cells is its transition from a proliferative to a differentiation stage. This process needs to be finely adjusted because it will determine the appropriate support of the germ cell line in adult life and the fertility of the individual. Immature Sertoli cells proliferate and several factors affect this process, including FSH, estra…

  Exploring possible new receptors and signaling pathways that may contribute to the modulatory effect of relaxin on proliferation and differentiation of Sertoli cells, AP.R

• Abstract

  Relaxin is a member of the family of insulin-related peptides, which interacts with a G-protein coupled receptor, RXFP1. Disruption of relaxin gene in males causes infertility, and studies from our laboratory have shown that relaxin and RXFP1 co-localize in Sertoli cells, RXFP1 is present in germ cells and relaxin induces Sertoli cell proliferation through a mechanism that seems to involv…

  Analysis of the role of relaxin in early and late stages of spermatogenesis, using co-cultures of Sertoli and germ cells, AP.R

• Abstract

  Estrogen plays a role in reproductive tissues both in females and in males, and also in non-reproductive tissues, including the brain. Physiological and pathophysiological effects of estrogen are mediated by three receptors (ERα, ERβ and the recent1y discovered GPR30) and include both changes in gene transcription and rapid cellular responses. The present project intends to anal…

  Estrogen receptors: expression, regulation, signaling, and function in the male reproductive tract, breast, and brain, AP.TEM

(Only some records are available in English at this moment)

• Abstract

  Relaxin is an insulin-related peptide with pleiotropic actions in the body. In 2002, the G protein-coupled receptor RXFP1 was identified as the relaxin receptor. However, although the relaxin knockout leads to infertility in males, the RXFP1 knockout does not perfectly mimic this phenotype. Furthermore, the most well known signaling pathway stimulated by RXFP1 is the increase of cAMP prod…

  Relaxin signaling in testis: investigation of the presence of isoforms of the RXFP1 receptor, NOS/NO signaling, and the possible participation of the glucocorticoid receptor, BP.IC

• Abstract

  Relaxin is an insulin-related peptide that interacts with the G-protein coupled receptor RXFP1. The male mice with a relaxin knockout is infertile, and previous studies from our laboratory revealed that relaxin and RXFP1 are expressed in germ cells, and relaxin stimulates the proliferation of Sertoli cells through a mechanism that involves activation of MEK/ERK1/2 and PI3K/AKT pathways. T…

  Effects of relaxin silencing in a co-culture model of Sertoli and germ cells, BP.IC

• Abstract

  Male fertility is controlled by a combination of hormonal signals that control the Sertoli cell production of the necessary factors for spermatogenesis. FSH and testosterone are the main regulators of spermatogenesis. Depending on the maturation stage of the Sertoli cells, these hormones activate signaling pathways such as cAMP/PKA, ERK1/2 or PI3K/AKT. Members of the PI3K/AKT and cAMP cas…

  Role of relaxin in different stages of Sertoli cell development: characterization of the intracellular signaling, effects on gene and protein expression and modulation by FSH, BP.DR

(Only some records are available in English at this moment)