Abstract
Introduction: Polycystic kidney disease (PKD) is one of the most common genetic disorders in humans, affecting over 500,000 people in the United States alone. It is characterized by progressive growth of kidney cysts leading to end stage renal disease in ~50% of the patients. Polycystin-1 (PC1) and polycystin-2 (PC2) are the protein products of the PKD1 and PKD2 genes respectively, with …