Abstract
eIF5A is the only protein known to contain the unusual amino acid residue hypusine. This residue is essential for eIF5A function and it is generated by a post-translational modification (hypusination) of a specific lisine residue depending on the polyamine spermidine. The role of GC7 (N1-guanil-1,7- diamin-heptane), an structural analogous of the poliamine spermidine, on growth inhibition…