Abstract
Relaxin is an insulin-related peptide with pleiotropic actions in the body. In 2002, the G protein-coupled receptor RXFP1 was identified as the relaxin receptor. However, although the relaxin knockout leads to infertility in males, the RXFP1 knockout does not perfectly mimic this phenotype. Furthermore, the most well known signaling pathway stimulated by RXFP1 is the increase of cAMP prod…