Flavia Leticia Martins graduated in Biological Sciences (Licenciatura mode) Mackenzie University (2015) and a degree in Biological Sciences (Bacharelado mode) Mackenzie University (2016). Two years of undergraduate research at the Heart Institute HC - FMUSP, under the guidance of Prof. Dr. Adriana Castello Costa Girardi. Currently a Master's student at the Faculty of Medicine of São Paulo - USP under the guidance of Prof. Dr. Adriana Castello Costa Girardi. She has experience in the area of physiology and molecular biology, with emphasis on kidney physiology. (Source: Lattes Curriculum)
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Inhibitors of the enzyme dipeptidyl peptidase IV (DPPIV) are antidiabetic agents which exert renoprotective effects, beyond the glycemic benefit, in humans and experimental models of cardiovascular and renal diseases. Inhibition of DPPIV reduces Na+/H+ exchanger 3 (NHE3)-dependent Na+ reabsorption in proximal renal tubule and this inhibitory effect is associated with the reduction of bloo…
A large body of clinical and experimental evidence documents the importance of the kidney in defining the blood pressure (BP) set point and pathogenesis of hypertension. Body fluid volumes and Na+ balance are maintained by the renal regulation of a series of apical Na+ transporters located along the nephron. Changes in the number and/or intrinsic activity of these transporters affect Na+ …
Studies conducted by numerous research laboratories, including ours, underscore the need for undertaking cardiorenal approaches to effectively contain the progression of certain cardiovascular diseases. Edema is the hallmark of congestive heart failure (HF). The most important causes of edema in HF are salt and water retention by the kidneys. The potential causes of altered renal handling…
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