CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF) (Institutional affiliation from the last research proposal) Birthplace: Cuba
Graduate In Chemistry at the University of Oriente (2000), MSc in "Integrated Coastal Zone Management" at the University of Oriente (2003), PhD in Chemistry at the University of Sao Paulo (2006-2009) and Post-Doctoral in Biochemistry at the University of Sao Paulo (2010). Research stages in Neurotoxicology (IIBB-CSIC, Spain, 2008, 2014), Toxicogenomic (UFZ, Germany, 2009) and Metallomics (Helmholtz Zentrum München, Germany, 2014). Professor of Environmental Chemistry, General Chemistry and Toxicology at the Federal University of São Paulo. Visiting Professor at Carleton University, Canada (2016-current). I have experience in Circular Bioeconomy, Environmental Bioinorganic Chemistry, including Synthesis, Chemical Speciation and Chemical Fractionation approaches. Additionally, I works on the development of protocols for studies of Environmental Toxicology, involving In-silico approaches and Evolutionary Toxicogenomics applied to alternative experimental models such as saccharomyces cerevisiae (yeast), Danio rerio (Zebrafish), primary cultures of granular cells of the cerebellum of Mus musculus ( mice). These approaches allow for the design, syntheses and evaluation of less harmful chemicals, subsequently reducing exposure and residuals in studies, principles that define the Green Toxicology. Pricipal scientific contributions involve the elucidation of mechanisms of neurotoxicology and neurodegeneration induced by chemical species of manganese, approaches development towards one health. (Source: Lattes Curriculum)
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Manganese (Mn) is the twelfth most abundant element in the earth's crust. Mn is an essential trace mineral in nutrition that can be neurotoxic and neurodegenerative via environmental and/or nutritional acute and chronic exposure, especially during stages of development. Studies from our group, applying "omics" approaches, have revealed that environmentally relevant concentrations of Mn2+ …
Manganese (Mn) is an essential trace mineral that can be (neuro)toxic, especially during developmental stages due to unclear mechanisms suggesting the need for additional and improved studies. We employ adverse outcome pathways (AOPs); a novel tool designed to provide a clear-cut mechanistic representation of critical toxicological effects that span over different layers of biological org…
(Only some records are available in English at this moment)
The Mn and their species are associated with others chemical species in both environment and physiological level. Toxicologically, these interactions can lead to synergistic, additives or an antagonistic effect, which are not always well known and has received little attention. Indeed, the traditional in vitro or in vivo experiments for risk assessment about Mn development neurotoxicity a…
Manganese (Mn) is essential for living organisms, playing an important role in nervous system function, bone mineralization, protein and energy metabolism, metabolic regulation and cellular protection. However, chronic exposure for this metal, mainly during early life stages, can lead to toxicity, with the central nervous system as the primary target. Indeed, Mn toxicity has been associat…
Manganese (Mn) is the twelfth most abundant element in the earth crust. Mn is an essential trace mineral in nutrition that can be (neuro)toxic, especially during developmental stages by unclear mechanisms that suggest additional and improved studies. In this way, adverse outcome pathways (AOPs) are novel tools designed to provide a clear-cut mechanistic representation of critical toxicolo…
Manganese (Mn) is essential for living organisms, playing an important role in nervous system function, bone mineralization, protein and energy metabolism, metabolic regulation and cellular protection. Nevertheless, chronic and/or acute exposure for this metal, mainly during early life stages can lead to neurotoxicity and dementia (cognitive and neurobehavioral impairment). Despite, the h…
| 9 / 7 | Completed research grants |
| 3 / 2 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 14 / 11 | All research grants and scholarships |
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