Abstract
Marfan Syndrome (MFS) is an autosomal dominant disease that affects the connective tissue. Has an incidence of 1 per 5000 individuals. The main clinical manifestations are progressive dilation and rupture of the aorta, bone overgrowth, scoliosis, chest deformities and retinal detachment. The MFS is caused by mutations in the FBN1 gene, that encodes the extracellular protein fibrillin-1, m…