CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Aline Santos is a professor of Cell Biology at the Institute of Biology at the State University of Campinas. She leads a multidisciplinary research team composed of biologists, biochemists, and physicists with a focus on DNA damage response signaling in cardiomyocytes. To gain new insights into the regulation of DNA repair mechanisms, they use a combination of biophysical, biochemical, and molecular biology techniques, including super-resolution microscopy, FRET and mass spectrometry, which allow the description of novel protein-protein interactions and its impact on cardiomyocyte DNA repair signaling. (Source: Lattes Curriculum)
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Heart diseases are frequently associated with mass increase (hypertrophy) and alterations of shape and dimension of cardiac chambers (remodeling) as an adaptive response to mechanic and neurohumoral stimuli. Hypertrophy mainly results from an increase of cardiomyocytes area, while remodeling is characterized by cell death and fibrosis, which are determinant factors for cardiac failure. Am…
Cardiovascular complications arising from antineoplastic therapies have become an emerging public health issue due to the growing population of cancer survivors. Cardiotoxicity induced by chemotherapeutic agents commonly used to treat various neoplasms, such as doxorubicin (dox), is a severe condition that can progress to chronic cardiomyopathy, congestive heart failure, and patient death…
Doxorubicin (dox) induced cardiotoxicity is one of the most important side effects of this chemotherapeutic drug, seeing as it can lead to oncological patients developing cardiomyopathies. Dox produces free radicals and inhibits topoisomerase II, which results in several DNA breaks followed by genotoxic stress culminating in cardiomyocyte death. Multiple studies show that Focal Adhesion K…
Protein tyrosine kinase 2 (PTK2) is a member of the non-receptor tyrosine kinase family crucial for the regulation of distinct cellular functions, such as cell migration and proliferation. In addition to its canonical roles in cytoplasmic signaling mediated by integrins and growth factor receptors, PTK2 acts in the nucleus, where it interacts with transcription factors and regulates proce…
Cardiovascular complications of antineoplastic therapies are considered an emerging public health problem, given the growing population of cancer survivors. Cardiotoxicity induced by chemotherapy agents, such as doxorubicin (doxo), is a serious condition that can progress to chronic cardiomyopathy, congestive heart failure, and patient death. Studies focusing on signaling activated by ant…
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Protein tyrosine kinase 2 (PTK2) is a member of the non-receptor tyrosine kinase family crucial for the regulation of distinct cellular functions, such as cell migration and proliferation. In addition to its canonical roles in cytoplasmic signaling mediated by integrins and growth factor receptors, PTK2 acts in the nucleus, where it interacts with transcription factors and regulates proce…
| 2 / 2 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 5 / 5 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 9 / 9 | All research grants and scholarships |
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