Abstract
Cutaneous melanoma (CM) deserves prominence among malignant tumors due to its high metastatic potential and therapeutic refractoriness. The Janus kinase/Signal tranducer (JAK/STAT) signaling pathway, with the JAK1, JAK2 and STAT3 proteins, regulates the development, progression and metastatic potential of the tumor. The JAK1, JAK2 and STAT3 proteins are encoded by polymorphic genes in hum…