Abstract
The molecular basis of adrenocortical tumors (ACT) is partially known. The oncogene Yes-Associated-Protein-1 is overexpressed in several common human cancers. In addition, YAP1 interacts with the Wnt/beta-catenin pathway and the Sonic hedgehog (SHH) pathway. Deregulation in these pathways appears to play an important role in adrenocortical tumorigenesis. Therefore, it is possible that abn…