Abstract
Mitofusins 1 (Mfn1) and 2 (MFN2) are transmembrane GTPases present in the outer mitochondrial membrane and being involved in the regulation of mitochondrial fusion. Since Mfn2 is also present in the membrane of the endoplasmic reticulum (ER), it is also responsible for regulating the morphology and the interaction of ER with the mitochondrion. Thus, there are increasing evidences that Mfn…