Abstract
Naproxen (NPX) is a non-steroidal anti-inflammatory used for the treatment of rheumatoid arthritis and osteoarthritis, isolated or as pharmacotherapeutic associations. However, NPX oral administration evokes significant adverse effects (such as toxicity to the gastrointestinal tract). In order to reduce systemic side effects, the intraarticular (IA) route has been proposed as an alternati…