Vinicius Kannen Cardoso

• Abstract

  Serotonin is a neurohormone with one of the most complex activity in humans and other animals. It modulates apetite, peristalsis, sleep, learning, memory, mood, growth, aging, reproduction, among many other events. Novel evidence suggests that the source of serotonin (5-HT; either epithelial or neural) expression is most important for the establishment of inflammatory bowel disease. Altho…

  Differentiating the effects of epithelial from the neural serotoninergic signalling during inflammation-related colon cancer, AP.JP

• Development of transgenic mouse strains to study neuroendocrine changes and colon tumors, BP.TT

• Abstract

  Serotonin (5-HT) is neurohormone with multiple effects in mammals. The intestinal 5-HT synthesis is initiated by the enzyme tryptophan hydroxylase I (Tph1) activity on tryptophan. This neuropeptide is believed to promote colon cancer. However, our unpublished findings (FAPESP 2014/ 06428-5) demonstrate that this neurohormone inhibits not only the formation of colon preneoplastic lesions b…

  Intestinal serotoninergic activity modulates the intensity of DNA damage, BP.IC

• Abstract

  Serotonin (5-HT) isneurohormone with multiple effects in mammals and has its synthesis initiated from tryptophan by the enzyme tryptophan hydroxylase I (Tph1). It has been thought that 5-HT promotes the colon tumor development, although recent data have shown that it inhibits the formation of preneoplastic lesions in the colon. Unpublished results from my Young Investigator Awards (FAPESP…

  Effects of colonic serotonergic activity on DNA damage inducing carcinogenesis Colon, BP.MS

(Only some records are available in English at this moment)