Abstract
Heterologous prime-boost vaccination using plasmid DNA followed by replication defective human recombinant adenovirus type 5 - both expressing the amastigote surface protein 2 (ASP-2) of Trypanosoma cruzi- is a powerful strategy to elicit CD8+ T cells, mainly CD8+ T effector memory cells (TEM), that mediated protective immunity against the parasite protozoan Trypanosoma cruzi. Specific TE…