Abstract
Background: Type I Interferon(IFN) is a key element in the pathogenesis of systemic lupus erythematosus (SLE). About half of lupus patients have predominant expression of interferon-induced genes in peripheral blood mononuclear cells (PBMC), known as interferon singnature. Interferon has a central role in autoimmunity acting as a bridge between innate and adaptive immune response. It is a…