Abstract
Glioblastoma (GBM) stem-like cells (GSC) represent the most undifferentiated and aggressive state of GBM malignant cells. GSC are postulated to be resistant against current therapy and able to self-renew and differentiate into the bulk cells of the tumour, playing a relevant role in GBM carcinogenesis and reoccurrence. Since its first experimental evidences, the enrichment of GSC in vitro…