Abstract
Skin is the first barrier protection against injuries, infections and is involved in immunoregulatory mechanisms. Proteases are play roles in these physiological and pathophysiological functions including skin desquamation. This project will focus on two tissue kallikrein 5 and7 (KLK5 and KLK7) highly expressed and functional in human skin. Both are serine proteases, but KLK5 such as tryp…