Abstract
Streptococcus pneumoniae (pneumococcus) is one of the main causes of pneumonia, meningitis and sepsis in children worldwide. Recent estimations show that approximately 400,000 children younger than 5 years old die annually with infections caused by S. pneumoniae worldwide. Pneumococcus surface protein A (PspA) is a well characterized antigen that confers protection in animal models, repre…