Abstract
Acute Myeloid Leukemia (AML) is a heterogeneous malignant hematologic neoplasm caused by the accumulation of mutations and molecular changes in Hematopoietic Stem Cells (HTC), culminating in the accumulation of abnormal and immature myeloid cells in the bone marrow and in ineffective hematopoiesis. Despite great advances in understanding the complexity involved in the biology and clinic o…