Abstract
Recently our group demonstrated FBLN1 and the CLDN6 genes have been stimulated by E2 and T3 in MCF-7 cells. Thus,our hypothesis is that thyroid hormone alters the expression of FBLN1 and CLDN6 without the need of translocation to the nucleus, by activation of phosphatidylinositol-3-kinase (PI3K) pathway. We intend to elucidate the pathway of action of E2 and T3 in the activation of these …