Adriano Silva Sebollela in research grants and scholarships supported by FAPESP.
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The deposition of abnormal protein aggregates is associated with several neurodegenerative diseases. The most prevalent, Alzheimer's disease (AD), is characterized by the brain accumulation of aggregates formed by the Abeta peptide. Although the pathogenesis of AD is not fully understood, strong evidence indicate that soluble Abeta oligomers (AbOs) play a central role in the molecular bas…
Toxic protein oligomers are believed to be the main culprit for the synaptic loss and cognitive decline in proteinopathies afflicting the central nervous system (CNS), as Alzheimer's, Parkinson, and prionoses. As a result, the interaction between oligomers and neurons is now seen as a preferential target for the development of novel therapeutic strategies against these neuropathologies. O…
Alzheimer's Disease (AD) is a proteinopathy responsible for most cases of dementia today. Its clinical manifestations are associated with neuronal damage and loss triggered by the binding of soluble ²-amyloid peptide oligomers (A²Os). The current project proposes using cultures of adult human brain tissue slices, prepared using tissue obtained from patients undergoing neurosurgical proced…
Neurotropic viruses can cause central nervous system (CNS) diseases. About 30% of confirmed encephalitis cases are attributed to viral infections. Despite that, the molecular mechanisms and cellular alterations resulting from viruses infections in the human brain are still not well characterized. Murine models have been widely used to elucidate mechanisms associated with viral infections,…
The present project proposes the use of organotypic cultures of adult human brain tissue, prepared using tissue obtained from patients undergoing neurosurgical treatments at Hospital das Clinicas in Ribeirão Preto, as a model for studying molecular and cellular changes associated with beta-amyloid peptide oligomers toxicity, and its relationship with Alzheimer's Disease. The slices in cul…
(Only some records are available in English at this moment)
Brain slice cultures maintain the cytoarchitecture and cell connections present in brain tissue and have been widely applied in neuroscience research. In our laboratory, we have developed a method for culturing adult human brain tissue under free-floating conditions. In the past few years, we have applied this model to study cellular and molecular aspects associated with the brain pathoge…
| 1 / 1 | Ongoing research grants |
| 1 / 1 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 15 / 12 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 20 / 17 | All research grants and scholarships |
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