Abstract
Von Willebrand factor (VWF) is a protein involved in homeostasis, responsible for mediating platelet adhesion and aggregation at sites of vascular injury. This protein is synthesized as pre-pro-VWF and contains a signal peptide, a propeptide known as VWF:AgII and a mature subunit. The mature subunit and the propeptide are secreted in equimolar amounts, though with different half-lives. Ad…