Abstract
The renal cell carcinoma (RCC) represents approximately 2 to 3% of human malignant tumors and is the most aggressive of urologic tumors. The most common is the subtype of RCC clear cell (ccRCC). Most patients have mutated gene tumor suppressor in von Hippel-Lindau (VHL) which results in increased transcription of several angiogenic factors such as vascular endothelial growth factor (VEGF)…