Abstract
The 2K-1C renal hypertension model is characterized by activation of the renin-angiotensin-aldosterone system (RAAS). Angiotensin II (Ang II) is the main peptide of RAAS that promotes vascular smooth muscle cells contraction by AT1 receptor activation. AT1 is expressed in endothelial cells and is involved in NADPH-oxidase (NOX) activation, increased production of reactive oxygen species (…