Abstract
Telomeres are nucleotides repetitive sequences (in mammals, TTAGGGn) coated by a specialized protein complex known as shelterins. Usually, the telomere length is maintained by the telomerase, containing the reverse transcriptase enzyme (TERT) and the RNA template (TERC), as well as associating proteins such as the dyskerin (encoded by DKC1 gene). Mutations in genes associated with telomer…