CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Bachelor's at Ciencias Farmaceuticas from Universidade de São Paulo (1985), M.Sc. at Microbiology and Immunology from Universidade Federal de São Paulo (1993) and Ph.D at Microbiology and Immunology from Universidade Federal de São Paulo with a period at the Department of Medical and Molecular Parasitology da New York University, under supervision of Dr. Moriya Tsuji and Dr. Ruth Nussenzweig (1997). Post-doctoral studies at the Unidade de Oncologia Experimental da Universidade Federal de São Paulo (2002). Associate Professor, Head of Tumor Immunobiology Laboratory at Microbiology, Immunology and Parasitology Department, Escola Paulista de Medicina, Universidade Federal de São Paulo. Experience on Immunology and Experimental Oncology. Has been working in Immune response and Tumor microenvironment, Immunomodulation and New compounds for cancer therapy, mainly tumor development and immune response in hyperglycemic environment,, immunomodulation, immunogenic cell death, interleukins, and evaluation of synthetic compounds aiming the development of new antitumor therapeutic alternatives. (Source: Lattes Curriculum)
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Epidemiological studies suggest a strong correlation between the occurrence of diabetes and cancer development. Aging, obesity, diet, and a sedentary lifestyle are risk factors associated with both diseases. Hyperglycemia and inflammation have been implicated in the association of diabetes and cancer. However, how these factors influence this association is not known. With this proposal w…
Studies on the structure and mechanisms of action of bioactive peptides and peptidases in experimental models of infectious diseases and cancer. All subprojects depend on an active sector of synthesis and analysis of peptides as installed at the Biophysics Department of UNIFESP. Peptides and peptidases are so broadly involved in the functioning of cells and multicellular organisms that vi…
Melanoma, the type of skin cancer showing the highest mortality rate, is classically treated with chemo and radiotherapy protocols, but the prognosis of the disease improves significantly only with early diagnosis. The efficacy of the currently available treatments is still very low for metastatic melanoma. Immunotherapeutic protocols have shown promising results. Good results with Ipilim…
The Free Radical Theory of Aging proposes that changes in the elderly result from an imbalance between oxidative damages and antioxidants defenses. Following oxidative stress, there is an increase in circulating factors, such as C-reactive protein and pro-inflammatory cytokines, e.g., IL-1, IL-6, TNF-alpha. These factors turn the body in a state of chronic inflammation, with prolonged act…
Melanoma originates from melanocytes (melanin-producing cells), and is a tumor with high metastatic potential and low effective available treatments (chemotherapy and radiotherapy), all of them showing severe undesirable side effects. Breast cancer is the second prevalent cancer worldwide and the most prevalent among women, being also difficult to control and treat. Tumor development can …
(Only some records are available in English at this moment)
| 2 / 2 | Completed research grants |
| 15 / 7 | Completed scholarships in Brazil |
| 17 / 9 | All research grants and scholarships |
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