CV Lattes
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Universidade de São Paulo (USP). Instituto de Química de São Carlos (IQSC) (Institutional affiliation from the last research proposal) Birthplace: Itália
graduation at Chimica from Università degli Studi di Roma La Sapienza (2014). Has experience in Chemistry, focusing on Organical Chemistry, acting on the following subjects: g4-ligands, g-quadruplex, oncogene promoters and binding affinity. (Source: Lattes Curriculum)
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The cruzain, major cysteine protease of Trypanosoma cruzi, is an essential enzyme for the parasite's life cycle and it has been used as a viable target for searching new enzyme inhibitors candidate as pharmaceutical drugs. The peptide-mimetic compound K777 inhibits cruzain at nanomolar concentrations, and acts by irreversible inhibition mechanism. Analogues or derivatives of K777 generall…
Cruzain is an established target for the identification of novel trypanocidal agents, but how good are in vitro/in vivo correlations for active compounds? This project aims at the development of computational models for the prediction of the properties of cruzain inhibitors that are Trypanosoma cruzi killers. We will systematically analyze structure-activity relationships (SARs), visualiz…
| 1 / 1 | Completed scholarships in Brazil |
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