CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
PhD student in Human Physiology in Biomedical Sciences Intitute (ICB) in University of São Paulo (USP), under the councelour Prof. Dr. William Tadeu Lara Festuccia. Currently, is a FAPESP-SP fellowship associated with the thematic project "Characterization of mTOR nutrient sensor involvement in the development of chronic metabolic diseases associated with obesity". Graduated in Biomedical Sciences at the State University of Londrina (UEL), being a fellow of Fundação Araucária/PR. e-mail: mileneortiz@usp.br (Source: Lattes Curriculum)
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In follow-up to the master's degree experiments (FAPESP#2016/05406-3), in this project of doctorate, we will test the hypothesis that the autophagy pathway is an important mediator of the metabolic, morphological and inflammatory alterations of adipose tissue in Obesity. During the master's, we performed an experimental protocol where wild-type C57BL6/J mice fed with control or high fat d…
In this proposal, we will test the hypothesis that autophagy is an important mediator of the metabolic, morphologic and inflammatory changes in adipose tissue found upon obesity (mTORC1 gain of function) or inactivation of mTORC1 (loss of function) in adipocytes. For this, we will conduct two different protocols: (1) C57BL6J fed with a chow or high fat diet will be treated or not with aut…
The central regulators of autophagy are the serine/threonine kinases unc-51 like autophagy activating kinase 1/2 (ULK1 and ULK2) that participate in the onset of the autophagic cellular process. These kinases in addition to initiate the autophagic cascade, seem to have interesting secondary roles in energy metabolism to coordinate the cellular response to starvation, such as increasing gl…
| 2 / 2 | Completed scholarships in Brazil |
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